Mechanisms of epilepsy

Epilepsy is a cyclical disorder of the brain that takes its root in uncoordinated neuronal activity. Our working hypothesis is that the epileptic brain operates on the verge of instability and that certain recurring brainstates are more favorable to the intrusion of frankly abnormal dynamics. Parallel advances in clinical and fundamental research help us understand why seizures occur at a given time and not at others? We advocate for the integration of fundamental insights, advanced computational strategies and pragmatic clinical approaches to ultimately improve the care of epilepsy patients who do not fully respond to medication.